diff --git a/esphome/components/md5/__init__.py b/esphome/components/md5/__init__.py
index 1af9ee0b2..1710b00e6 100644
--- a/esphome/components/md5/__init__.py
+++ b/esphome/components/md5/__init__.py
@@ -1,7 +1,17 @@
 import esphome.codegen as cg
+from esphome.core import CORE
+from esphome.helpers import IS_MACOS
 
 CODEOWNERS = ["@esphome/core"]
 
 
 async def to_code(config):
     cg.add_define("USE_MD5")
+
+    # Add OpenSSL library for host platform
+    if CORE.is_host:
+        if IS_MACOS:
+            # macOS needs special handling for Homebrew OpenSSL
+            cg.add_build_flag("-I/opt/homebrew/opt/openssl/include")
+            cg.add_build_flag("-L/opt/homebrew/opt/openssl/lib")
+        cg.add_build_flag("-lcrypto")
diff --git a/esphome/components/md5/md5.cpp b/esphome/components/md5/md5.cpp
index 866f00eda..26554e4d3 100644
--- a/esphome/components/md5/md5.cpp
+++ b/esphome/components/md5/md5.cpp
@@ -39,6 +39,44 @@ void MD5Digest::add(const uint8_t *data, size_t len) { br_md5_update(&this->ctx_
 void MD5Digest::calculate() { br_md5_out(&this->ctx_, this->digest_); }
 #endif  // USE_RP2040
 
+#ifdef USE_HOST
+MD5Digest::~MD5Digest() {
+  if (this->ctx_) {
+    EVP_MD_CTX_free(this->ctx_);
+  }
+}
+
+void MD5Digest::init() {
+  if (this->ctx_) {
+    EVP_MD_CTX_free(this->ctx_);
+  }
+  this->ctx_ = EVP_MD_CTX_new();
+  EVP_DigestInit_ex(this->ctx_, EVP_md5(), nullptr);
+  this->calculated_ = false;
+  memset(this->digest_, 0, 16);
+}
+
+void MD5Digest::add(const uint8_t *data, size_t len) {
+  if (!this->ctx_) {
+    this->init();
+  }
+  EVP_DigestUpdate(this->ctx_, data, len);
+}
+
+void MD5Digest::calculate() {
+  if (!this->ctx_) {
+    this->init();
+  }
+  if (!this->calculated_) {
+    unsigned int len = 16;
+    EVP_DigestFinal_ex(this->ctx_, this->digest_, &len);
+    this->calculated_ = true;
+  }
+}
+#else
+MD5Digest::~MD5Digest() = default;
+#endif  // USE_HOST
+
 }  // namespace md5
 }  // namespace esphome
 #endif
diff --git a/esphome/components/md5/md5.h b/esphome/components/md5/md5.h
index b0da2c0a3..6ff651b02 100644
--- a/esphome/components/md5/md5.h
+++ b/esphome/components/md5/md5.h
@@ -5,6 +5,10 @@
 
 #include "esphome/core/hash_base.h"
 
+#ifdef USE_HOST
+#include <openssl/evp.h>
+#endif
+
 #ifdef USE_ESP32
 #include "esp_rom_md5.h"
 #define MD5_CTX_TYPE md5_context_t
@@ -31,7 +35,7 @@ namespace md5 {
 class MD5Digest : public HashBase {
  public:
   MD5Digest() = default;
-  ~MD5Digest() override = default;
+  ~MD5Digest() override;
 
   /// Initialize a new MD5 digest computation.
   void init() override;
@@ -47,7 +51,12 @@ class MD5Digest : public HashBase {
   size_t get_size() const override { return 16; }
 
  protected:
+#ifdef USE_HOST
+  EVP_MD_CTX *ctx_{nullptr};
+  bool calculated_{false};
+#else
   MD5_CTX_TYPE ctx_{};
+#endif
 };
 
 }  // namespace md5
diff --git a/tests/components/hmac_md5/test.host.yaml b/tests/components/hmac_md5/test.host.yaml
new file mode 100644
index 000000000..dade44d14
--- /dev/null
+++ b/tests/components/hmac_md5/test.host.yaml
@@ -0,0 +1 @@
+<<: !include common.yaml